BME 100: Introduction to Biomedical Engineering

A rigorous introduction to biomedical engineering that provides the historical and social context of BME though contemporary emerging areas within BME. Specific areas covered in depth include: bioelectricity and biosensors (action potentials to signal processing), bioimaging (invasive and non-invasive), genetic engineering (with ethical discussions), and biostatistics. Hands-on computational modeling introduces the physiological concept of positive and negative feedback loops in the body. Emphasis is placed on ways engineers view the living system by using design based approaches and computation.

Prerequisites: BME major or BNG minor or departmental consent

SBC:     TECH

3 credits

BME 120: Programming Fundamentals in Biomedical Engineering

This course will introduce the theory and fundamentals of computer programming specifically designed for the applications in biomedical engineering. Students will learn the basic computer architecture and the interaction between the computer hardware, operating system and application software. The course focus will be on the programming control logic and style critical to all programming languages including C and MATLAB. several core and elective courses in biomedical engineering use MATLAB as a key programming language, and therefore MATLAB will be the primary language used to teach the above mentioned programming principles. This course will also serve as the foundation where the students can pursue further advanced programming skills.

Prerequisite: BME Major or BNG Minor

3 credits

BME 200: Bioengineering in Extreme Environments

Technology at the human-engineering interface that enables human life in harsh environments, including high temperatures, high altitude, deep sea and outer space. Emphasis on the technical design requirements of the bio-engineering interface that will enable life to thrive. Physiological limits to survival will be examined within the context of when the bio-engineering technology is required. This course may not be taken for major credit.

SBC:     SNW, TECH

3 credits

BME 203: Emergent Biodesign

This course is designed to provide students with early team-based design experience. Students will learn CAD, 3D printing, microcontroller programming and have hands-on experience in prototyping to solve bite-sized real engineering problems. Students will engage in teamwork, and be exposed to clinical settings to learn how to identify clinical needs.

Prerequisites: BME major; U2 or higher

3 credits

BME 205: Clinical Challenges of the 21st Century

Technology used by current medical practice, focusing on weekly topics associated with a specific disease state. Technology used to diagnose and treat these disease states will be rigorously examined. Weekly topics will include: cancer, cardiovascular disease, Alzheimer's, obesity, diabetes, osteoporosis, osteoarthritis, and organ transplant. Key disease states will be presented in physiological and cellular depth. This course may not be taken for major credit.

SBC:     SNW, TECH

3 credits

BME 210: Applied Biostatistics

Students will learn an array of biostatistical techniques to correctly describe and analyze experimental data. The emphasis will be on how to select and apply statistical methods for common statistical tasks encountered in biomedical engineering, rather than on the math underlying individual methods. Statistical software will be heavily used for active learning. Not for credit in addition to AMS 102, 110, POL 201, PSY 201 and SOC 202.

Prerequisite: BME 100; BME Major; U2 standing

3 credits

BME 212: Biomedical Engineering Research Fundamentals

Introduction to data collection and analysis in the context of biophysical measurements commonly used by bioengineers. Statistical measures, hypothesis testing, linear regression, and analysis of variance are introduced in an application-oriented manner. Data collection methods using various instruments, A/D boards, and PCs as well as LabView, a powerful data collection computer package. This course has an associated fee. Please see www.stonybrook.edu/coursefees for more information.

Prerequisites: BME major; BME 100

Pre- or Corequisite: BIO 202

3 credits

BME 260: Statics and Dynamics in Biological Systems

Fundamentals of engineering statics and dynamics on biological systems will be covered using vector methods. Covered topics will include free body diagrams, equilibrium of systems, rectilinear kinetics and kinematics, angular kinetics and kinematics, work, energy and momentum of biological systems. In parallel, the necessary anatomy and physiology of the organ systems including the musculoskeletal system, the nervous system and the cardiovascular system will be covered. This material will lead to a discussion on kinesiology.

Prerequisites: BME 100; AMS 161; PHY 125 or 131 or 141

4 credits

BME 271: Introduction to Electric Circuits and Bioelectricity

As an introductory course to circuit design, we begin with fundamental theory of circuit analysis, including lumped time-invariant models of resistors, capacitors, inductors, Ohm's Law, Kirchoff's Laws, nodal and mesh analysis techniques, two-port equivalent circuits, and steady-state AC circuits. The applications of basic circuit analysis techniques in biomedical instrumentation and biological circuitry will be discussed throughout the entire class. In the final part of the course, the principles of cell electrophysiology, bio-potentials and electrical interactions with tissue will be studied. Not for credit in addition to ESE 271.

Prerequisites: AMS 161 or MAT 127 or 132; PHY 127/134 or PHY 132/134 or PHY 142

3 credits

BME 300: Writing in Biomedical Engineering

See Requirements for the Major in Biomedical Engineering, Upper-Division Writing Requirement.

Prerequisites: WRT 102; U3 or U4 standing; BME major

Corequisite: Any upper division BME course; perm. of instructor or Undergraduate Director

0 credit, S/U grading

BME 301: Bioelectricity

In this course, we will study how electrical signals are generated and propagated in biological tissue. From the basics of Ohm's Law, as well as the laws that govern diffusion and electric field theory, we will develop mathematical models of bioelectric processes as well as perform simulations of these processes using Matlab. Understanding these signals at the cell and membrane level will provide a foundation for understanding proper nerve, cardiac and muscle function, as well as disease conditions. Using this understanding, we will examine state-of-the-art applications in current literature.

Prerequisites: BME 120; BME 271 or ESE 271; BIO 202

Pre or Corequisite: BME 212

3 credits

BME 302: Research Fundamentals and Communication

Students will learn about scientific research and how to become a scientist. Specifically, course content will revolve around the experimental design process, securing of research funding, and the execution of experiments, data analysis, and interpretation. Emphasis will be placed on conveying scientific results in oral and written form, adhering to professional standards in Biomedical Engineering. As a capstone project, students will design and perform their own experiments in groups and submit an individual manuscript suitable for publication in a scientific journal.

Prerequisite: BIO 204; BME 100; BME 210

3 credits

BME 303: Biomechanics

Illuminates the principles of mechanics and dynamics that apply to living organisms, from cells to humans to Sequoia trees. The behavior of organisms is examined to observe how they are constrained by the physical properties of biological materials. Locomotion strategies (or the lack thereof) are investigated for the forces and range of motions required and energy expenditures. Includes the relationship between form and function to illustrate how form dominates behavior. Presents the physiological effects of mechanical stresses on organs, pathologies that develop from abnormal stress, and how biological growth and adaptation arise as a natural response to the mechanics of living.

Prerequisite: BME 260 or MEC 260

Pre- or Corequisite: BIO 202

3 credits

BME 304: Genetic Engineering

An introduction to the realm of molecular bioengineering with a focus on genetic engineering. Includes the structure and function of DNA, the flow of genetic information in a cell, genetic mechanisms, the methodology involved in recombinant DNA technology and its application in society in terms of cloning and genetic modification of plants and animals (transgenics), biotechnology (pharmaceutics, genomics), bioprocessing (production and process engineering focusing on the production of genetically engineered products.), and gene therapy. Production factors such as time, rate, cost, efficiency, safety, and desired product quality are also covered. Considers societal issues involving ethical and moral considerations, consequences of regulation, as well as risks and benefits of genetic engineering.

Prerequisites: BME 100; BIO 202 or 203

DEC:     H
SBC:     STAS

3 credits

BME 305: Biofluids

The fundamentals of heat transfer, mass transfer, and fluid mechanics in the context of physiological systems. Techniques for formulating and solving biofluid and mass transfer problems with emphasis on the special features and the different scales encountered in physiological systems, from the organ and the tissue level down to the molecular transport level.

Prerequisites: AMS 261 or MAT 203; AMS 361 (or MAT 303 or MAT 305); BME 260 (or MEC 260 and MEC 262)

Pre- or Corequisite: BIO 202; BME 212

3 credits

BME 310: Introduction to Biomedical Optics and Ultrasound

The course will introduce fundamental concepts of tissue optics and ultrasound, light/ultrasound tissue interaction, and optical/ultrasound instrumentation, as well as current preclinical and clinical applications of light and ultrasound for diagnosis and therapy in biomedicine.

Prerequisite: BME 271

3 credits

BME 311: Fundamentals of Macro to Molecular Bioimaging

This course will cover the fundamentals of modern imaging technologies, including techniques and applications within medicine and biomedical research. The course will also introduce concepts in molecular imaging with the emphasis on the relations between imaging technologies and the design of target specific probes as well as unique challenges in the design of probes of each modality: specificity, delivery, and amplification strategies. The course includes visits to clinical sites.

Prerequisite: BME 212

3 credits

BME 312: LabVIEW Programming in Engineering

LabVIEW is the leading software development platform that enables engineers and scientists to create and deploy powerful measurement and control applications and prototypes with minimal time. This course will systematically teach LabVIEW programming with the focus on the data flow model. The highlighted course topics are basic programming logics, graphic user interface design and parallel programming. It will also teach hardware integration using LabVIEW built-in functions for data acquisition, instrument control, measurement analysis and data presentation. Hands-on projects and demonstrations will be implemented throughout the course to enhance the knowledge learned in classroom. At the end of the course, students will be offered the free exam for Certified LabVIEW Associated Developer provided by National Instruments for future career development.

3 credits

BME 313: Bioinstrumentation

The course content is directed to the basic concept of biomedical instrumentation and medical device. Main focus is on the application of the latest computer technology in bioinstrumentation. The course covers the topics such as basic sensors in biomedical engineering, biological signal measurement and conditioning, data acquisition and data analysis. In addition, the course will teach in detail the LabVIEW programming, a graphics tool for virtual instrumentation. The students will learn the techniques of collecting biological signals using basic sensors, and acquisition and analysis of biological signals using software and data acquisition hardware. The students will gain the hands-on experience in design of medical devices. This course will help students to develop skills to build instrumentation for laboratory research and prototyping medical devices.

Prerequisite: BME 271 or ESE 271

3 credits

BME 353: Introduction to Biomaterials

This course provides an introduction to materials, including metals, ceramics, polymers, composites, coatings, and adhesives that are used in the human body. It emphasizes the physiochemical properties of materials that are considered important to meet the criteria specified for the implant and device applications (e.g. strength, modulus, fatigue and corrosion resistance, conductivity), and to be compatible with the biological environment (e.g. nontoxic, noncarcinogenic, etc.). Not for credit in addition to CME 371/ESM 453 or BME 504.

Prerequisites: BME100 and BME 212

3 credits

BME 354: Advanced Biomaterials

This course is an overview of the applications of biomaterials. Here the emphasis is on the unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application/field. Since biomaterials applications entail their direct or indirect contact with humans, the various practical aspects associated with biomaterials such as sterilization, packaging, evaluating device failures as well as regulatory guidelines will be covered.

Prerequisite: BME 353 or ESM 453

3 credits

BME 361: Data Science with Python

This course will introduce the basics of Python programming and how to address real-world data analysis challenges by programming. It provides an overview of standard library and coding techniques with functions, loops, classes and objectives, strings, lists, tuples, and also introduces a few advanced packages to process biomedical data and images. Students will learn this object-oriented programming language to address practical problems in the class. Both lectures and laboratories are provided for this course.

Prerequisites: BME 120 and MAT 125/126 or AMS 151 or MAT 131

3 credits

BME 371: Biological Microfluidics

This one semester course will outline theory and applications of special fluid handling conditions associated with living systems. Microfluids will be examined with respect to aquaporin channels (single file molecular water movement), intercellular fluid transport mechanisms, microvascular convective fluid movement (2 phase flow), and transvascular fluid movement (3 pore theory) with reference to the similarity of each to flow in fabricated microchannels.

Prerequisite: BME 305

3 credits

BME 381: Nanofabrication in Biomedical Applications

Theory and applications of nanofabrication. Reviews aspects of nanomachines in nature with special attention to the role of self-lubrication, intracellular or interstitial viscosity, and protein-guided adhesion. Discusses current nanofabricated machines to perform the same tasks and considers the problems of lubrication, compliance, and adhesion. Self-assembly mechanisms of nanofabrication with emphasis on cutting-edge discovery to overcome current challenges associated with nanofabricated machines.

Prerequisites: CHE 132; BME 100

Pre- or Corequisite: BIO 202 or 203

3 credits

BME 402: Contemporary Biotechnology

This course will provide an introduction into the realm of modern biotechnology and its applications. This course introduces the historical development of biotechnology and its contemporary applications, including, bioproducts and biofuels, microbial fermentation/bioprocessing, aerobic bioreactors, modeling and simulation, metabolism and enzyme kinetics, metabolic engineering, bioremediation and environmental sustainability and human medicine. Further, societal issues involving ethical and moral implications, perceptions and fears, intellectual property, safety, risks and regulatory issues, as well as economics of biotechnology will be discussed.

Prerequisite: BME 304

3 credits

BME 404: Essentials of Tissue Engineering

Topics covered are: developmental biology (nature's tissue engineering), mechanisms of cel-cell and cell-matrix interactions, biomaterial formulation, characterization of biomaterial properties, evaluation of cell interactions with biomaterials, principles of designing an engineered tissue. Considers manufacturing parameters such as time, rate, cost, efficiency, safety and desired product quality as well as regulatory issues.

Prerequisites: BIO 202 or 203; CHE 132

Advisory Prerequisites: CHE 321 and 322

3 credits

BME 420: Computational Biomechanics

Introduces the concepts of skeletal biology; mechanics of bone, ligament, and tendon; and linear and nonlinear properties of biological tissues. Principles of finite differences method (FDM) and finite elements method (FEM) to solve biological problems. Both FDM and FEM are applied to solve equations and problems in solid and porous media. Requires knowledge of Fortran or C programming.

Prerequisites: BME 303

3 credits

BME 430: Quantitative Human Physiology

This course will provide an introduction to the study of quantitative physiology. This course will introduce the physical, chemical and mathematical foundation of physiology. That knowledge will then be applied to membranes, transport, metabolisms, excitable cells and various organ systems.

Prerequisites: BIO 202 and AMS 261 or MAT 203

3 credits

BME 440: Biomedical Engineering Design

Introduction to product development from the perspective of solving biomedical, biotechnological, environmental, and ergonomic problems incorporating appropriate engineering standards and multiple realistic constraints. Teamwork in design, establishing customer needs, writing specifications, and legal and financial issues are covered in the context of design as a decision-based process. A semester-long team design project follows and provides the opportunity to apply concepts covered in class.

Prerequisites: BME major; U4 standing; BME 301 and 305

Partially fulfills: CER, ESI, EXP+, SBS+, SPK, STEM+, WRTD

3 credits

BME 441: Senior Design Project in Biomedical Engineering

Formulation of optimal design problems in biomedical and physiological settings. Introduces optimization techniques for engineering design and modeling for compact and rapid optimization of realistic biomedical engineering problems. Necessary conditions for constrained local optimum with special consideration for the multiple realistic constraints in which the product designed should function in terms of the settings (corporal, ex-corporal, biological, etc.), the engineering standards, and the safety considerations involved which are unique to biomedical engineering. Students carry out the detailed design of projects chosen early in the semester. A final design report is required. This course has an associated fee. Please see www.stonybrook.edu/coursefees for more information.

Prerequisite: BME 440

Partially fulfills: CER, ESI, EXP+, SBS+, SPK, STEM+, WRTD

3 credits

BME 444: Experiential Learning

This course is designed for students who engage in a substantial, structured experiential learning activity in conjunction with another class. Experiential learning occurs when knowledge acquired through formal learning and past experience are applied to a "real-world" setting or problem to create new knowledge through a process of reflection, critical analysis, feedback and synthesis. Beyond-the-classroom experiences that support experiential learning may include: service learning, mentored research, field work, or an internship.

Prerequisite: WRT 102 or equivalent; permission of the instructor and approval of the EXP+ contract (http://sb.cc.stonybrook.edu/bulletin/current/policiesandregulations/degree_requirements/EXPplus.php)

SBC:     EXP+

0 credit, S/U grading

BME 461: Biosystems Analysis

Fundamentals of the linear time series analyses framework for modeling and mining biological data. Applications range from cardiorespiratory; renal blood pressure, flow, and sequence; to gene expression data. Tools of data analysis include Laplace and Z transforms, convolution, correlation, Fourier transform, transfer function, coherence function, various filtering techniques, and time-invariant and time-varying spectral techniques.

Prerequisites: BME 212 and 301

3 credits

BME 475: Undergraduate Teaching Practicum

Students assist the faculty in teaching by conducting recitation or laboratory sections that supplement a lecture course. The student receives regularly scheduled supervision by the faculty instructor. May be used as an open elective and repeated once.

Prerequisites: BME major; U4 standing; a minimum g.p.a. of 3.00 in all Stony Brook courses and a grade of B or better in the course in which the student is to assist; or permission of the department

SBC:     EXP+

3 credits

BME 476: Undergrad Teaching Practicum II

Students assist the faculty in teaching and learn independent teaching skills while observed by the instructor. May be used as an open elective.

Prerequisites: BME major; U4 standing; a minimum g.p.a. of 3.00 in all Stony Brook courses and a grade of B+ or better in the course in which the student is to assist; instructor and departmental approval.

SBC:     EXP+

3 credits

BME 481: Biosensors

A comprehensive introduction to the basic features of biosensors. Discusses types of most common biological agents (e.g. chromophores, fluorescence dyes) and the ways in which they can be connected to a variety of transducers to create complete biosensors for biomedical applications. Focus on optical biosensors and systems (e.g. fluorescence spectroscopy, microscopy), and fiberoptically-based biosensing techniques . New technologies such as molecular beacons, Q-dots, bioMEMs, confocal microscopy and multiphoton microscopy, and OCT will be referenced.

Prerequisites: BIO 202; BME 271 or ESE 271

3 credits

BME 488: Biomedical Engineering Internship

Participation in off-campus biomedical engineering practice. Students are required to submit a proposal to the undergraduate program director at the time of registration that includes the location, immediate supervisor, nature of the project, and hours per week for the project. One mid-semester report and one end of semester report are required. May be repeated up to a limit of 12 credits.

Prerequisites: BME 212 and permission of undergraduate program director

SBC:     EXP+

3-6 credits

BME 494: Honors Seminar on Research

The course outlines components of biomedical research vs design that includes experimental design, data recording, analysis and presentation at scientific meetings, as well as engineering design schematics, patents, and presentations to angel investors. The course culminates with an Honors Thesis Proposal that follows either a research (hypothesis testing) or design (prototype construction) pathway.

Prerequisite: U3 standing and acceptance into the BME Honors program.

1 credit

BME 495: Honors Independent Research

The course involves research (hypothesis testing) or engineering design (prototype construction) that the student completes under the supervision of the faculty member. The course culminates with an Honors Thesis draft (Fall semester) or Honors Thesis that is orally defended (Spring semester). Both BME 494 and BME 495 must be taken to qualify to graduate with Honors in BME.

Prerequisite: BME 494

3 credits

BME 499: Research in Biomedical Engineering

An independent research project with faculty supervision.

Prerequisites: Permission of instructor

0-3 credits